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How I treat...chronic myeloid leukemia
Hafraoui K , Humblet-Baron S , Baron F , Beguin Y , Fillet G
Rev Med Liege 2003, 58(1),7-12Abstract : This review article describes the identification of the tyrosine kinase BCR/ABL as the hallmark of chronic myeloid leukemias (CML) as well as the development of a specific inhibitor of this tyrosine kinase, the STI571 (Glivec, imatinib mesylate). The authors discuss the results of a phase I and three phase II trials reporting the efficacy of STI571 as treatment for CML patients and propose two simplified algorithms that may help to guide decision-making for the individual patient
