Abstract : In the context of Acute Pulmonary Edema (APE), the old school moto was LMNOP, for “Lasix-Morphine-Nitrates-Oxygen-Positive Pressure”. However, this mnemonic, while not entirely inaccurate, deserves revision or at least a slight reinterpretation. APE remains a well-known condition in emergency departments, with a high mortality rate. Despite its prevalence, management recommendations have seen minimal evolution over the past four decades, with references dating back to a 1974 article in the New England Journal of Medicine that already advocated for the triplet of Lasix-Oxygen-Nitrates, a recommendation still present in the 2021 ESC guidelines. In this article, we will discuss the management and potential updates in the treatment of this common pathology.