-
High anion gap metabolic acidosis (pyroglutamic acidosis) induced by chronic acetaminophen use
Tchougang Nono J. , Mistretta V. , Noirot I. , Canivet JL. , Damas P.
Rev Med Liege 2018, 73(1),39-42Abstract : Acetaminophen is the most consumable analgesic in the world in the form of medical prescription or self-medication. It is one of the active ingredients most often involved in voluntary poisoning. Lethal dose of acetaminophen classically induces acute hepatic failure on hepatic necrosis. Chronic intake of sub-lethal doses (i.e. near recommended therapeutic doses) of acetaminophen in the presence of certain risk factors may be responsible for another much less recognized pathological manifestation: severe metabolic acidosis with an increased anion gap due to the accumulation of 5-oxoproline or pyroglutamic acid.
