Abstract : Sneddon’s syndrome is a rare vascular disease affecting mainly skin and brain arterioles leading to their occlusion. The two main features of this syndrome are livedo racemosa and ischemic stroke. Here, we describe the case of a 37-year-old woman with a past medical history of Moskowitz’s syndrome and migraine, and a 2-year history of livedo racemosa and Raynaud’s phenomenon. She presented with acute aphasia related to cortical ischemic stroke. Extensive diagnostic workup allowed to diagnose a Sneddon’s syndrome. Her symptoms improved on a platelet aggregation inhibitor (aspirin), and speech therapy. This condition can be associated with other disorders affecting small vessels such as illustrated in this case with Moskowitz’s syndrome.