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The MAP kinase cascade. A key target for treatments in skin cancerology
Piérard G.E. , Piérard-Franchimont C. , Leonard B. , Delvenne P.
Rev Med Liege 2013, 68(12),650-654Abstract : Intracellular Mitogen-Activated Protein Kinases (MAPK) form a signalling cascade of proteins involved in cell proliferation, differentiation, migration and apoptosis. They are particularly activated by some cytokines, hormones, environmental stress and in skin cancers as well. A series of pharmacological compounds targeting the MAPK cascade dramatically changes skin cancerology, at least during a transient phase of the metastatic process. Some combined treatments possibly increase the median overall survival.
