Abstract : In the treatment of depression, the main objective is to reach complete remission. Unfortunately, this objective remains difficult in clinical practice. In fact, complete remission is frequently considered as an unrealistic objective. It is clear that recovering from major depression is a complicated objective, but it is realistic. In the present paper, we describe the case of a patient suffering from treatment-resistant chronic depression that remitted with a combination of duloxetine (Cymbalta®) and aripiprazole (Abilify®).