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VEGF inhibitors in ophthalmology
Thys J. , Dupont G. , Rakic J.M.
Rev Med Liege 2009, 64(5-6),323-326Abstract : The exsudative form of age-related macular degeneration (AMD) is characterized by the development of choroidal neovascularization (CNV) under the retina driven in part by the vascular endothelial growth factor. Several VEGF inhibitors have recently been produced for ocular administration. This review will focus on ranibizumab which is a specific antibody neutralizing all VEGF isoforms. The development, pharmacokinetics, clinical efficacy, current and future indications of ranibizumab are discussed.
