Abstract : Over the last ten years, progress in evidencebased medicine coupled with technological breakthroughs and introduction of new drugs have deeply changed the management of our patients. In the field of hormone therapy, lower dosages of estrogens and new progestins have increased tolerance and non-contraceptive benefits of oral contraceptives, while lower-doses, new progestins, new routes of administration have optimized the benefit/risk balance for the treatment of menopause. About 500,000 cycles of IVF are performed worldwide each year, optimizing male and female fertility, with less multiple pregnancies, and use of new recombinant gonadotropin, LHRH agonists/antagonists, new ovarian tissue cryopreservation techniques, etc…